2022
Bozic I, Rusterholz T, Mikutta C, Del Rio-Bermudez C, Nissen C, Adamantidis A. Coupling between the prelimbic cortex, nucleus reuniens, and hippocampus during NREM sleep remains stable under cognitive and homeostatic demands Eur J Neurosci. (2023) 57(1):106-128.
Pack AI, Adamantidis A, Stone KL, Gozal D. SLEEP: Next Steps. Sleep. (2022) 45(12):zsac196.
Chiffi G, Grandgirard D, Stöckli S, Valente LG, Adamantidis A, Leib SL. Tick-borne encephalitis affects sleep-wake behavior and locomotion in infant rats Cell Biosci. (2022) 12(1):121.
Aime M, Adamantidis AR. Sleep to Survive Predators. Neurosci Bull. (2022) 38(9):1114-1116
Aime M, Calcini N, Borsa M, Campelo T, Rusterholz T, Sattin A, Fellin T & Adamantidis A. Paradoxical somato-dendritic decoupling supports cortical plasticity during REM sleep. Science (2022) 376(6594):724-730.
Adamantidis A. How the gut talks to the brain. Science. (2022) 376(6590):248-249.
The evolutionarily conserved miRNA-137 targets the neuropeptide hypocretin/orexin and modulates the wake to sleep ratio. Holm A, Possovre ML, Bandarabadi M, Moseholm K, Justinussen JL, Bozic I, Lemcke R, Arribat Y, Amati F, Silahtaroglu A, Juventin M, Adamantidis A, Tafti M, Kornum BR. PNAS (2022) 119(17):e2112225119.
Duffet L, Kosar S, Panniello M, Viberti B, Bracey E, Zych AD, Radoux-Mergault A, Zhou X, Dernic J, Ravotto L, Tsai YC, Figueiredo M, Tyagarajan SK, Weber B, Stoeber M, Gogolla N, Schmidt MH, Adamantidis AR, Fellin T, Burdakov D, Patriarchi T. Author Correction: A genetically encoded sensor for in vivo imaging of orexin neuropeptides Nat Methods. (2022) 19(4):505.
Duffet L, Kosar S, Panniello M, Viberti B, Bracey E, Zych AD, Radoux-Mergault A, Zhou X, Dernic J, Ravotto L, Tsai YC, Figueiredo M, Tyagarajan SK, Weber B, Stoeber M, Gogolla N, Schmidt MH, Adamantidis AR, Fellin T, Burdakov D, Patriarchi T. 2022. A genetically encoded sensor for in vivo imaging of orexin neuropeptides. Nat Methods. 2022 Feb;19(2):231-241.
Smith NA, Helmreich DL, Adamantidis A, Bovolenta P, Foxe JJ, Smith Y, Vaidya VA. "Diversity matters series"-The Black In Neuro movement. Eur J Neurosci. (2022) 55(2):343-349.
2021
Oesch LT, Adamantidis AR. 2021. How REM sleep shapes hypothalamic computations for feeding behavior. Trends Neurosci. 2021 Dec;44(12):990-1003.
Oesch LT, Adamantidis AR. 2021. Sleep and Metabolism: Implication of Lateral Hypothalamic Neurons. Front Neurol Neurosci. 2021;45:75-90.
Gazea M, Furdan S, Sere P, Oesch L, Molnár B, Di Giovanni G, Fenno LE, Ramakrishnan C, Mattis J, Deisseroth K, Dymecki SM, Adamantidis AR, Lőrincz ML. 2021. Reciprocal Lateral Hypothalamic and Raphe GABAergic Projections Promote Wakefulness. J Neurosci. 2021 Jun 2;41(22):4840-4849.
2020
Adamantidis, A.R., Schmidt, M.H., Carter, M.E., Burdakov, D., Peyron, C., Scammel, T.E. 2020. A circuit perspective on narcolepsy. Sleep. 2020 May 12;43(5):zsz296.
Bandarabadi, M., Herrera, C.G., Gent, T.C., Bassetti, C., Schindler, K., Adamantidis, A.R. 2020. A role for spindles in the onset of rapid eye movement sleep. Nat Commun. 2020 Oct 16;11(1):5247.
Battagello, D. S.,Lorenzon, A. R., Diniz, G. B.,Motta-Teixeira, L. C.,Klein, M. O.,Ferreira, J. G. P., Arias, C. M., Adamantidis, A., Sita, L. V., Cipolla-Neto, J., Bevilacqua, Emaf, Sawchenko, P. E., Bittencourt, J. C.2020. The rat mamary gland as a novel site of expression of melanin-concentrating hormone receptor 1mRNA and its protein Immunorectivity. Front Endocrinol. 2020 Jul 31;11:463.
Cisse, Y., Ishibashi, M., Jost, J., Mainville, L., Adamantidis, A., Leonard, C.S., Jones, B.E. 2020. Discharge and role of GABA ponukogitomesencephalic neurons in cortical activity and sleep-wake states examined by optogenetics and juxtacellular recordings in mice. J. Neurosci. 2020 Jul 29;40(31):5970-5989.
Collins, B., Pierre-Ferrer, S., Muheim, C., Lukacsovich, D., Cai, Y., Spinnler, A., Herrera, C. G., Wen, S., Winterer, J., Belle, M. D. C., Piggins, H. D., Hastings, M., Loudon, A., Yan, J., Foldy, C., Adamantidis, A., Brown, S. A. 2020. Circadian VIPergic Neurons of the suprachiasmatic Nuclei Sculpt the sleep-wake cycle. Neuron. 2020 Nov 11;108(3):486-499.e5.
Diniz, G. B., Battagello, D. S., Klein, M. O., Bono, B. S. M., Ferreira, J. G. P., Motta-Teixeira, L. C., Duarte, J. C. G., Presse, F., Nahon, J. L., Adamantidis, A., Chee, M. J., Sita, L. V., Bittencourt, J. C. 2020. Ciliary melanin-concentrating hormone receptor 1 (MCHR1) is widely distributed in the murine CNS in a sex-independent manner. J Neurosci Res. 2020 Oct;98(10):2045-2071.
Facchin, L., Schone, C., Mensen, A., Bandarabadi, M., Pilotto, F., Saxena, S., Libourel, P. A., Bassetti, C. L. A., Adamantidis, A. R. 2020. Slow Waves Promote Sleep-Dependent Plasticity and Functional Recovery after Stroke. J Neurosci. 2020 Nov 4;40(45):8637-8651.
Hubbard, J., Gent, T. C., Hoekstra, M. M. B., Emmenegger, Y., Mongrain, V., Landolt, H. P., Adamantidis, A. R., Franken, P. 2020. Rapid fast-delta decay following prolonged wakefulness marks a phase of wake-inertia in NREM sleep. Nat Commun. 2020 Jun 19;11(1):3130.
Karnani, M. M., Schone, C., Bracey, E. F., Gonzalez, J. A., Viskaitis, P., Li, H. T., Adamantidis, A., Burdakov, D. 2020. Role of spontaneous and sensory orexin network dynamics in rapid locomotion initiation. Prog Neurobiol. 2020 Apr;187:101771.
Oesch, L. T., Gazea, M., Gent, T. C., Bandarabadi, M., Gutierrez Herrera, C., Adamantidis, A. R. 2020. REM sleep stabilizes hypothalamic representation of feeding behavior. Proc Natl Acad Sci USA. 2020 Aug 11;117(32):19590-19598.
Pace, M., Colombi, I., Falappa, M., Freschi, A., Bandarabadi, M., Armirotti, A., Encarnacion, B. M., Adamantidis, A. R., Amici, R., Cerri, M., Chiappalone, M., Tucci, V. 2020. Loss of Snord116 alters cortical neuronal activity in mice: a preclinical investigation of Prader-Willi syndrome. Hum Mol Genet. 2020 Jul 29;29(12):2051-2064.
2019
Adamantidis, A. R., Gutierrez Herrera, C., & Gent, T. C. 2019. Oscillating circuitries in the sleeping brain. Nat Rev Neurosci. 2019 Dec;20(12):746-762.
Bandarabadi, M., Boyce, R., Gutierrez Herrera, C., Bassetti, C., Williams, S., Schindler, K., & Adamantidis, A. 2019. Dynamic modulation of theta-gamma coupling during REM sleep. Sleep. 2019 Dec 24;42(12):zsz182.
Bassetti, C. L. A., Adamantidis, A., Burdakov, D., Han, F., Gay, S., Kallweit, U., Khatami, R., Koning, F., Kornum, B. R., Lammers, G. J., Liblau, R. S., Luppi, P. H., Mayer, G., Pollmacher, T., Sakurai, T., Sallusto, F., Scammell, T. E., Tafti, M., & Dauvilliers, Y. 2019. Narcolepsy - clinical spectrum, aetiopathophysiology, diagnosis and treatment. Nat Rev Neurol, 15(9): 519-539.
Komagata, N., Latifi, B., Rusterholz, T., Bassetti, C. L. A., Adamantidis, A., & Schmidt, M. H. 2019. Dynamic REM Sleep Modulation by Ambient Temperature and the Critical Role of the Melanin-Concentrating Hormone System. Curr Biol. 2019 Jun 17;29(12):1976-1987.e4.
Mensen, A., Pigorini, A., Facchin, L., Schone, C., D'Ambrosio, S., Jendoubi, J., Jaramillo, V., Chiffi, K., Eberhard-Moscicka, A. K., Sarasso, S., Adamantidis, A., Muri, R. M., Huber, R., Massimini, M., & Bassetti, C. 2019a. Corrigendum to: "Sleep as a model to understand neuroplasticity and recovery after stroke: Observational, perturbational and interventional approaches" [Journal of Neuroscience Methods Volume 313, 1 February 2019, Pages 37-43]. J Neurosci Methods, 321: 79.
Mensen, A., Pigorini, A., Facchin, L., Schone, C., D'Ambrosio, S., Jendoubi, J., Jaramillo, V., Chiffi, K., Eberhard-Moscicka, A. K., Sarasso, S., Adamantidis, A., Muri, R. M., Huber, R., Massimini, M., & Bassetti, C. 2019b. Sleep as a model to understand neuroplasticity and recovery after stroke: Observational, perturbational and interventional approaches. J Neurosci Methods, 313: 37-43.
Miladinovic, D., Muheim, C., Bauer, S., Spinnler, A., Noain, D., Bandarabadi, M., Gallusser, B., Krummenacher, G., Baumann, C., Adamantidis, A., Brown, S. A., & Buhmann, J. M. 2019. SPINDLE: End-to-end learning from EEG/EMG to extrapolate animal sleep scoring across experimental settings, labs and species. PLoS Comput Biol, 15(4): e1006968.
Muller Herde, A., Mihov, Y., Kramer, S. D., Mu, L., Adamantidis, A., Ametamey, S. M., & Hasler, G. 2019. Chronic Nicotine Exposure Alters Metabotropic Glutamate Receptor 5: Longitudinal PET Study and Behavioural Assessment in Rats. Neurotox Res, 36(4): 806-816.
2018
Adamantidis A.; Lüthi a. (2018). Optogenetic dissection of Sleep-Wake States In Vitro and In Vivo. Handbook of experimental pharmacology, 2019;253:125-151. Epub. Springer Link
2017
Boyce, Richard; Williams, Sylvain; Adamantidis, A. (2017). REM sleep and memory. Current opinion in neurobiology, 44, S. 167-177. Elsevier
Ferreira, Jozelia Gomes Pacheco; Bittencourt, Jackson Cioni; Adamantidis, A. (2017). Melanin-concentrating hormone and sleep. Current opinion in neurobiology, 44, S. 152-158. Elsevier
Lörincz, Magor L; Adamantidis, A. (2017). Monoaminergic control of brain states and sensory processing: Existing knowledge and recent insights obtained with optogenetics. Progress in neurobiology, 151, S.237-253. Elsevier
Boyce, Richard; Adamantidis, A. (2017). REM Sleep on It! Neuropsychopharmacology, 42(1), S. 375. Nature Publishing Group
Gutierrez Herrera, Carolina; Ponomarenko, Alexey; Korotkova, Tatiana; Burdakov, Denis; Adamantidis, A. (2017). Sleep & Metabolism: the multitasking ability of lateral hypothalamic inhibitory circuitries. Frontiers in neuroendocrinology, 44, S. 27-34. Elsevier
Pace, Marta; Adamantidis, A.; Facchin, Laura; Bassetti, Claudio (2017). Role of REM Sleep, Melanin Concentrating Hormone and Orexin/Hypocretin Systems in the Sleep Deprivation Pre-Ischemia. PLoS ONE, 12(1), E0168430. Public Library of Science
Gent, Thomas Clifford; Adamantidis, A. (2017). Anaesthesia and sleep. Clinical and translational neuroscience, 1(1), 2514183X1772628. Sage Publications.
2016
Sclafani, Anthony, Adamantidis, A.; Ackroff, Karen (2016). MCH receptor deletion does not impair glucose-conditioned flavor preferences in mice. Physiology & behavior, 163, S. 239-244. Elsevier
Kassiri, Hossein; Chemparathy, Aditi; Salam, M Tariqus; Boyce, Richard; Adamantidis A.; Genov, Roman (2016). Electronic Sleep Stage Classifiers: A Survey and VLSI Design Methodology. IEEE transactions on biomedical circuits and systems, 11(1), S. 1-12. Institute of Electrical and Electronics Engineers IEEE
Boyce, Richard; Glasgow, Stephen D; Williams, Sylvain; Adamantidis, A. (2016). Causal evidence for the role of REM sleep theta rhythm in contextual meomory consolidation. Science, 352(6287), S. 812-816. American Associaton for the Advancement of Science
Gutierrez Herrera, Carolina; Cadvieco, Marta Carus; Jego, Sonia; Ponomarenko, Alexey; Korotkova, Tatiana; Adamantidis, A. (2016) Hypothalamic feedforward inhibition of thalamocortical network controls arousal and consciousness. Nature neuroscience, 19(2), S. 290-298. Nature America
González, J Antonio; Iordanidou, Panagiota; Strom, Molly; Adamantidis, A.; Burdakov, Denis (2016). Awake dynamics and brain-wide direct inputs of hypthalamic MCH and orexin networks. Nature communications, 7(11395), S. 11395. Nature Publishing Group
2015
Adamantidis A.; Arber, Silvia; Bains, Jaideep S; Bamberg, Ernst; Bonci, Antonello; Buzsáki, György; Cardin, Jessica A; Costa, Rui M; Dan, Yang; Goda, Yukiko; Graybiel, Ann M; Häusser, Michael; Hegemann, Peter; Huguenard, John R; Insel, Thomas R; Janak, Patricia H; Johnston, Daniel; Josselyn, Sheena A; Koch, Christof; Kreitzer, Anatol C; ... (2015). Optogenetics: 10 years after ChR2 in neurons - views from the community. Nature neuroscience, 18(9), S.1202-1212. Nature America
Gutierrez Herrera, Carolina; Adamantidis, A. (2015). An integrated microprobe for the brain. Nature biotechnology, 33(3), S. 259-260. Nature America
Colby-Milley, Jessica; Cavanagh, Chelsea; Jego, Sonia; Breitner, John C S; Quirion, Rémi; Adamantidis, A. (2015). Sleep-Wake Cycle Dysfunction in the TgCRND8 Mouse Model of Alzheimer's Disease: From Early to Advanced Pathological Stages. PLoS ONE, 10(6), e0130177. Public Library of Science
Bassetti, Claudio; Ferini-Strambi, L.; Brown, S.; Adamantidis, A.; Benedetti, F.; Bruni, O.; Cajochen, C; Dolenc-Groselj, L.; Ferri, R.; Gais, S.; Huber, R.; Khatami, Ramin; Lammers, G.J.; Luppi, P. H.; Manconi, M.; Nissen, C.; Nobili, L.; Peugneux, P.; Pollmächter, T.; Randerath, W.; ... (2015). Neurology and psychiatry: waking up to opportunities of sleep.: State of the art and clinical/research priorities for the next decade. European journal of neurology, 22(10), S. 1337-1354. Blackwell Science
Adamantidis, A. (2015). Modern neurosciences: with or without optogenetics? médecine / sciences, 31(3), S. 231-232 EDP Sciences
Adamantidis, A. (2015). Sleep: the sound of a local alarm clock. Current Biology, 25(1), R49-R51. Cell Press
2014
Adamantidis A., Zhang, Feng; de Lecea, Luis; Deisseroth, Karl (2014). Optogenetics: opsins and optical interfaces in neuroscience. Cold Spring Harbor protocols, 2014(8), S. 815-822. Cold Spring Harbor Laboratory
Adamantidis A., Zhang, Feng; de Lecea, Luis; Deisseroth, Karl (2014). Establishing a fiber-optic-based optical neural interface. Cold Spring Harbor protocols, 2014(8), S. 839-844. Cold Spring Harbor Laboratory
Schöne C, Apergis-Schoute J, SakuraiT, Adamantidis A., Burdakov D. Cotransmission of orexin and glutamate enables parallel, non-redundant outputs from histamine neurons. Cell Reports. 2014 In Press.
Luppi, PH., Adamantidis A., Fort P. A The neurophysiology and neurobiology of sleep ESRS 40th Anniversary book, In press.
Adamantidis A., Carter, M.E. and de Lecea, L. Optogenetic control of arousal neurons.Shaw, P., Tafti, M. & Thorpy, M. The Genetic Basis of Sleep and Sleep Disorders. Cambridge University Press, In Press
2013
Conductier G, Martin AO, Risold PY, Jego S, Lavoie R, Lafont C, Mollard P, Adamantidis A., Nahon JL. Control of ventricular ciliary beating by the melanin concentrating hormone-expressing neurons of the lateral hypothalamus: a functional imaging survey. Front Endocrinol. 2013 Nov 25;4:182
Jego S, Glasgow SD, Herrera CG, Ekstrand M, Reed SJ, Boyce R, Friedman J, Burdakov D, Adamantidis A.. Optogenetic identification of a rapid eye movement sleep modulatory circuit in the hypothalamus. Nat Neurosci. 2013 Nov;16(11):1637-43.
Zhang Z, Cordeiro Matos S, Jego S, Adamantidis A., Séguéla P. Norepinephrine drives persistent activity in prefrontal cortex via synergistic α1 and α2 adrenoceptors. PLoS One. 2013 Jun 13;8(6):e66122.
Conductier G, Brau F, Viola A, Langlet F, Ramkumar N, Dehouck B, Lemaire T, Chapot R, Lucas L, Rovère C, Maitre P, Hosseiny S, Petit-Paitel A, Adamantidis A., Lakaye B, Risold PY, Prévot V, Meste O, Nahon JL, Guyon A. Melanin-concentrating hormone regulates beat frequency of ependymal cilia and ventricular volume. Nat Neurosci. 2013 Jul;16(7):845-7.
Jego S, Adamantidis A. MCH neurons: vigilant workers in the night. Sleep. 2013 Dec 1;36(12):1783-6.
Carter ME, de Lecea L, Adamantidis A. Functional wiring of hypocretin and LC-NE neurons: implications for arousal. Front Behav Neurosci. 2013 May 20;7:43.
2012
Schöne, C., Cao, Z.F.H., Apergis-Schoute, J., Adamantidis, A., Sakurai, T., and Burdakov, D. Optogenetic probing of fast glutamatergic transmission from hypocretin/orexin to histamine neurons in situ. J. Neurosci.32, 12437–12443. (2012).
Sherwood, A., Wosiski-Kuhn, M., Nguyen, T., Holland, P.C., Lakaye, B., Adamantidis, A., and Johnson, A.W. The role of melanin-concentrating hormone in conditioned reward learning. Eur. J. Neurosci.36, 3126–3133. (2012).
de Lecea, L., Carter, M.E., and Adamantidis, A. Shining Light on Wakefulness and Arousal. Biol.
older publications
Adamantidis, A.R., Tsai, H.-C., Boutrel, B., Zhang, F., Stuber, G.D., Budygin, E.A., Touriño, C., Bonci, A., Deisseroth, K., and de Lecea, L. Optogenetic interrogation of dopaminergic modulation of the multiple phases of reward-seeking behavior. J. Neurosci. 31, 10829–10835. (2011).
Karnani, M.M., Apergis-Schoute, J., Adamantidis, A., Jensen, L.T., de Lecea, L., Fugger, L., and Burdakov, D. Activation of central orexin/hypocretin neurons by dietary amino acids. Neuron72, 616–629. (2011).
Adamantidis, A. & de Lecea, L. Optogenetic Probing of Hypocretin Regulation of Wakefulness. In Narcolepsy. Baumann, C.R., Bassetti, C.L., and Scammell, T.E. Springer Eds. (2011).
Adamantidis, A.R., Zhang, F., de Lecea, L. and Deisseroth, K.D. Optogenetics: Opsins and Optical Interfaces in Neuroscience in “Imaging in Neuroscience: A Laboratory Manual”, Edited By Fritjof Helmchen, Arthur Konnerth,
Zhang, F., Tsai,H.C., Airan, R.D., Stuber, G.D., Adamantidis, A.R., de Lecea, L., Bonci, A. and Deisseroth, K.D.Optogenetics in Freely Moving Mammals: Dopamine and Reward in “Imaging in Neuroscience: A Laboratory Manual”, Edited By Fritjof Helmchen, Arthur Konnerth, Series Editor, Rafael Yuste. Cold Spring Harbor Laboratory Press. (2011)Series Editor, Rafael Yuste. Cold Spring Harbor Laboratory Press. (2011)
Zhang, F., Cong, L., Stuber, G.D., Adamantidis, A., and Deisseroth, K. (2011). Analysis of Neuronal Circuits with Optogenetics. Springer, Humana Press, pp. 207–223.
Zhang F.*, Gradinaru V.*, Adamantidis A.R.*, Durand R., Airan R.D., de Lecea L., Deisseroth K. Optogenetic interrogation of neural circuits: technology for probing mammalian brain structures. Nat Protoc. 5(3):439-56. (2010).
Carter, M.E., Yizhar, O., Chikahisa, S., Nguyen, H., Adamantidis, A., Nishino, S., Deisseroth, K., and de Lecea, L. Tuning arousal with optogenetic modulation of locus coeruleus neurons. Nat. Neurosci.13, 1526–1533. (2010).
Pachoud, B. *, Adamantidis, A. *, Ravassard, P., Luppi, P.-H., Grisar, T., Lakaye, B., and Salin, P.-A. Major impairments of glutamatergic transmission and long-term synaptic plasticity in the hippocampus of mice lacking the melanin-concentrating hormone receptor-1. J. Neurophysiol. (London) 104, 1417–1425. (2010).
Adamantidis, A., Carter, M.C., and de Lecea, L. Optogenetic deconstruction of sleep-wake circuitry in the brain. Front Mol Neurosci 2, 31. (2010).
Carter, M.E., Adamantidis, A., Ohtsu, H., Deisseroth, K., and de Lecea, L. Sleep homeostasis modulates hypocretin-mediated sleep-to-wake transitions. J. Neurosci. 29, 10939–10949. (2009).
Tsai, H.-C. *, Zhang, F. *, Adamantidis, A., Stuber, G.D., Bonci, A., de Lecea, L., and Deisseroth, K. Phasic firing in dopaminergic neurons is sufficient for behavioral conditioning. Science324, 1080–1084. (2009).
Adamantidis, A., and de Lecea, L. A role for Melanin-Concentrating Hormone in learning and memory. Peptides 30, 2066–2070. (2009a).
Adamantidis, A., and de Lecea, L. The hypocretins as sensors for metabolism and arousal. J. Physiol. (Lond.) 587, 33–40. (2009b).
Adamantidis A., de Lecea L. Sleep and metabolism: shared circuits, new connections. Trends Endocrinol Metab. 19(10):362-70.(2008)
Adamantidis A., Salvert D., Goutagny R., Lakaye B., Gervasoni D., Grisar T., Luppi P.H., Fort P. Sleep architecture of the melanin-concentrating hormone receptor 1-knockout mice. Eur. J. Neurosci. 27(7):1793-800 (2008)
Adamantidis, A.R. *, Zhang, F., * Aravanis, A.M., Deisseroth, K., and de Lecea, L. Neural substrates of awakening probed with optogenetic control of hypocretin neurons. Nature 450, 420–424. (2007).
Adamantidis, A. *, Thomas, E. *, Foidart, A., Tyhon, A., Coumans, B., Minet, A., Tirelli, E., Seutin, V., Grisar, T., and Lakaye, B. Disrupting the melanin-concentrating hormone receptor 1 in mice leads to cognitive deficits and alterations of NMDA receptor function. Eur. J. Neurosci. 21, 2837–2844. (2005).