Adamantidis A.; Lüthi A. (2018). Optogenetic Dissection of Sleep-Wake States In Vitro and In Vivo. Handbook of experimental pharmacology, Epub. Springer Link


Boye, Richard; Williams, Sylvain; Adamantidis, A. (2017). REM sleep and memory. Current opinion in neurobiology, 44, S. 167-177. Elsevier

Ferreira, Jozelia Gomes Pacheco; Bittencourt, Jackson Cioni; Adamantidis, A. (2017). Melanin-concentrating hormone and sleep. Current opinion in neurobiology, 44, S. 152-158. Elsevier

Lörincz, Magor L; Adamantidis, A. (2017). Monoaminergic control of brain states and sensory processing: Existing knowledge and recent insights obtained with optogenetics. Progress in neurobiology, 151, S.237-253. Elsevier

Boyce, Richard; Adamantidis, A. (2017). REM Sleep on It! Neuropsychopharmacology, 42(1), S. 375. Nature Publishing Group

Gutierrez Herrera, Carolina; Ponomarenko, Alexey; Korotkova, Tatiana; Burdakov, Denis; Adamantidis, A. (2017). Sleep & Metabolism: the multitasking ability of lateral hypothalamic inhibitory circuitries. Frontiers in neuroendocrinology, 44, S. 27-34. Elsevier

Pace, Marta; Adamantidis, A.; Facchin, Laura; Bassetti, Claudio (2017). Role of REM Sleep, Melanin Concentrating Hormone and Orexin/Hypocretin Systems in the Sleep Deprivation Pre-Ischemia. PLoS ONE, 12(1), E0168430. Public Library of Science

Gent, Thomas Clifford; Adamantidis, A. (2017). Anaesthesia and sleep. Clinical and translational neuroscience, 1(1), 2514183X1772628. Sage Publications.


Sclafani, Anthony, Adamantidis, A.; Ackroff, Karen (2016). MCH receptor deletion does not impair glucose-conditioned flavor preferences in mice. Physiology & behavior, 163, S. 239-244. Elsevier

Kassiri, Hossein; Chemparathy, Aditi; Salam, M Tariqus; Boyce, Richard; Adamantidis A.; Genov, Roman (2016). Electronic Sleep Stage Classifiers: A Survey and VLSI Design Methodology. IEEE transactions on biomedical circuits and systems, 11(1), S. 1-12. Institute of Electrical and Electronics Engineers IEEE

Boyce, Richard; Glasgow, Stephen D; Williams, Sylvain; Adamantidis, A. (2016). Causal evidence for the role of REM sleep theta rhythm in contextual meomory consolidation. Science, 352(6287), S. 812-816. American Associaton for the Advancement of Science

Gutierrez Herrera, Carolina; Cadvieco, Marta Carus; Jego, Sonia; Ponomarenko, Alexey; Korotkova, Tatiana; Adamantidis, A. (2016) Hypothalamic feedforward inhibition of thalamocortical network controls arousal and consciousness. Nature neuroscience, 19(2), S. 290-298. Nature America

González, J Antonio; Iordanidou, Panagiota; Strom, Molly; Adamantidis, A.; Burdakov, Denis (2016). Awake dynamics and brain-wide direct inputs of hypthalamic MCH and orexin networks. Nature communications, 7(11395), S. 11395. Nature Publishing Group


Adamantidis A.; Arber, Silvia; Bains, Jaideep S; Bamberg, Ernst; Bonci, Antonello; Buzsáki, György; Cardin, Jessica A; Costa, Rui M; Dan, Yang; Goda, Yukiko; Graybiel, Ann M; Häusser, Michael; Hegemann, Peter; Huguenard, John R; Insel, Thomas R; Janak, Patricia H; Johnston, Daniel; Josselyn, Sheena A;  Koch, Christof; Kreitzer, Anatol C; ... (2015). Optogenetics: 10 years after ChR2 in neurons - views from the community. Nature neuroscience, 18(9), S.1202-1212. Nature America

Gutierrez Herrera, Carolina; Adamantidis, A. (2015). An integrated microprobe for the brain. Nature biotechnology, 33(3), S. 259-260. Nature America

Colby-Milley, Jessica; Cavanagh, Chelsea; Jego, Sonia; Breitner, John C S; Quirion, Rémi; Adamantidis, A. (2015). Sleep-Wake Cycle Dysfunction in the TgCRND8 Mouse Model of Alzheimer's Disease: From Early to Advanced Pathological Stages. PLoS ONE, 10(6), e0130177. Public Library of Science

Bassetti, Claudio; Ferini-Strambi, L.; Brown, S.; Adamantidis, A.; Benedetti, F.; Bruni, O.; Cajochen, C; Dolenc-Groselj, L.; Ferri, R.; Gais, S.; Huber, R.; Khatami, Ramin; Lammers, G.J.; Luppi, P. H.; Manconi, M.; Nissen, C.; Nobili, L.; Peugneux, P.; Pollmächter, T.; Randerath, W.; ... (2015). Neurology and psychiatry: waking up to opportunities of sleep.: State of the art and clinical/research priorities for the next decade. European journal of neurology, 22(10), S. 1337-1354. Blackwell Science

Adamantidis, A. (2015). Modern neurosciences: with or without optogenetics? médecine / sciences, 31(3), S. 231-232 EDP Sciences

Adamantidis, A. (2015). Sleep: the sound of a local alarm clock. Current Biology, 25(1), R49-R51. Cell Press



Adamantidis A., Zhang, Feng; de Lecea, Luis; Deisseroth, Karl (2014). Optogenetics: opsins and optical interfaces in neuroscience. Cold Spring Harbor protocols, 2014(8), S. 815-822. Cold Spring Harbor Laboratory

Adamantidis A.Zhang, Feng; de Lecea, Luis; Deisseroth, Karl (2014). Establishing a fiber-optic-based optical neural interface. Cold Spring Harbor protocols, 2014(8), S. 839-844. Cold Spring Harbor Laboratory

Schöne C, Apergis-Schoute J, SakuraiT, Adamantidis A., Burdakov D. Cotransmission of orexin and glutamate enables parallel, non-redundant outputs from histamine neurons. Cell Reports. 2014 In Press.

Luppi, PH., Adamantidis A.,  Fort P. A The neurophysiology and neurobiology of sleep ESRS 40th Anniversary book, In press.

Adamantidis A., Carter, M.E. and de Lecea, L. Optogenetic control of arousal neurons.Shaw, P., Tafti, M. & Thorpy, M. The Genetic Basis of Sleep and Sleep Disorders. Cambridge University Press, In Press



Conductier G, Martin AO, Risold PY, Jego S, Lavoie R, Lafont C, Mollard P, Adamantidis A., Nahon JL. Control of ventricular ciliary beating by the melanin concentrating hormone-expressing neurons of the lateral hypothalamus: a functional imaging survey. Front Endocrinol. 2013 Nov 25;4:182

Jego S, Glasgow SD, Herrera CG, Ekstrand M, Reed SJ, Boyce R, Friedman J, Burdakov D, Adamantidis A.. Optogenetic identification of a rapid eye movement sleep modulatory circuit in the hypothalamus. Nat Neurosci. 2013 Nov;16(11):1637-43.

Zhang Z, Cordeiro Matos S, Jego S, Adamantidis A., Séguéla P. Norepinephrine drives persistent activity in prefrontal cortex via synergistic α1 and α2 adrenoceptors. PLoS One. 2013 Jun 13;8(6):e66122.

Conductier G, Brau F, Viola A, Langlet F, Ramkumar N, Dehouck B, Lemaire T, Chapot R, Lucas L, Rovère C, Maitre P, Hosseiny S, Petit-Paitel A, Adamantidis A., Lakaye B, Risold PY, Prévot V, Meste O, Nahon JL, Guyon A. Melanin-concentrating hormone regulates beat frequency of ependymal cilia and ventricular volume. Nat Neurosci. 2013 Jul;16(7):845-7.

Jego S, Adamantidis A. MCH neurons: vigilant workers in the night. Sleep. 2013 Dec 1;36(12):1783-6.

Carter ME, de Lecea L, Adamantidis A. Functional wiring of hypocretin and LC-NE neurons: implications for arousal. Front Behav Neurosci. 2013 May 20;7:43.



Schöne, C., Cao, Z.F.H., Apergis-Schoute, J., Adamantidis, A., Sakurai, T., and Burdakov, D. Optogenetic probing of fast glutamatergic transmission from hypocretin/orexin to histamine neurons in situ. J. Neurosci.32, 12437–12443. (2012).

Sherwood, A., Wosiski-Kuhn, M., Nguyen, T., Holland, P.C., Lakaye, B., Adamantidis, A., and Johnson, A.W. The role of melanin-concentrating hormone in conditioned reward learning. Eur. J. Neurosci.36, 3126–3133. (2012).

de Lecea, L., Carter, M.E., and Adamantidis, A. Shining Light on Wakefulness and Arousal. Biol. Psychiatry, 1–7. (2012).



Adamantidis, A.R., Tsai, H.-C., Boutrel, B., Zhang, F., Stuber, G.D., Budygin, E.A., Touriño, C., Bonci, A., Deisseroth, K., and de Lecea, L. Optogenetic interrogation of dopaminergic modulation of the multiple phases of reward-seeking behavior. J. Neurosci. 31, 10829–10835. (2011).

Karnani, M.M., Apergis-Schoute, J., Adamantidis, A., Jensen, L.T., de Lecea, L., Fugger, L., and Burdakov, D. Activation of central orexin/hypocretin neurons by dietary amino acids. Neuron72, 616–629. (2011).

Adamantidis, A. & de Lecea, L. Optogenetic Probing of Hypocretin Regulation of Wakefulness. In Narcolepsy. Baumann, C.R., Bassetti, C.L., and Scammell, T.E. Springer Eds. (2011).

 Adamantidis, A.R., Zhang, F., de Lecea, L. and Deisseroth, K.D. Optogenetics: Opsins and Optical Interfaces in Neuroscience in “Imaging in Neuroscience: A Laboratory Manual”, Edited By Fritjof Helmchen, Arthur Konnerth,

Zhang, F., Tsai,H.C., Airan, R.D., Stuber, G.D., Adamantidis, A.R., de Lecea, L., Bonci, A. and Deisseroth, K.D.Optogenetics in Freely Moving Mammals: Dopamine and Reward in “Imaging in Neuroscience: A Laboratory Manual”, Edited By Fritjof Helmchen, Arthur Konnerth, Series Editor, Rafael Yuste. Cold Spring Harbor Laboratory Press. (2011)Series Editor, Rafael Yuste. Cold Spring Harbor Laboratory Press. (2011)

Zhang, F., Cong, L., Stuber, G.D., Adamantidis, A., and Deisseroth, K. (2011). Analysis of Neuronal Circuits with Optogenetics. Springer, Humana Press, pp. 207–223.



Zhang F.*, Gradinaru V.*, Adamantidis A.R.*, Durand R., Airan R.D., de Lecea L., Deisseroth K. Optogenetic interrogation of neural circuits: technology for probing mammalian brain structures. Nat Protoc. 5(3):439-56. (2010).

Carter, M.E., Yizhar, O., Chikahisa, S., Nguyen, H., Adamantidis, A., Nishino, S., Deisseroth, K., and de Lecea, L. Tuning arousal with optogenetic modulation of locus coeruleus neurons. Nat. Neurosci.13, 1526–1533. (2010).

Pachoud, B. *, Adamantidis, A. *, Ravassard, P., Luppi, P.-H., Grisar, T., Lakaye, B., and Salin, P.-A. Major impairments of glutamatergic transmission and long-term synaptic plasticity in the hippocampus of mice lacking the melanin-concentrating hormone receptor-1. J. Neurophysiol. (London) 104, 1417–1425. (2010).

Adamantidis, A., Carter, M.C., and de Lecea, L. Optogenetic deconstruction of sleep-wake circuitry in the brain. Front Mol Neurosci 2, 31. (2010).



Carter, M.E., Adamantidis, A., Ohtsu, H., Deisseroth, K., and de Lecea, L. Sleep homeostasis modulates hypocretin-mediated sleep-to-wake transitions. J. Neurosci.  29, 10939–10949. (2009).

Tsai, H.-C. *, Zhang, F. *, Adamantidis, A., Stuber, G.D., Bonci, A., de Lecea, L., and Deisseroth, K. Phasic firing in dopaminergic neurons is sufficient for behavioral conditioning. Science324, 1080–1084. (2009).

 Adamantidis, A., and de Lecea, L. A role for Melanin-Concentrating Hormone in learning and memory. Peptides 30, 2066–2070. (2009a).

 Adamantidis, A., and de Lecea, L. The hypocretins as sensors for metabolism and arousal. J. Physiol. (Lond.) 587, 33–40. (2009b).


Older Publications

Adamantidis A., de Lecea L. Sleep and metabolism: shared circuits, new connections. Trends Endocrinol Metab. 19(10):362-70.(2008)

Adamantidis A., Salvert D., Goutagny R., Lakaye B., Gervasoni D., Grisar T., Luppi P.H., Fort P. Sleep architecture of the melanin-concentrating hormone receptor 1-knockout mice. Eur. J. Neurosci. 27(7):1793-800 (2008)

Adamantidis, A.R. *, Zhang, F., * Aravanis, A.M., Deisseroth, K., and de Lecea, L. Neural substrates of awakening probed with optogenetic control of hypocretin neurons. Nature 450, 420–424. (2007).

Adamantidis, A. *, Thomas, E. *, Foidart, A., Tyhon, A., Coumans, B., Minet, A., Tirelli, E., Seutin, V., Grisar, T., and Lakaye, B. Disrupting the melanin-concentrating hormone receptor 1 in mice leads to cognitive deficits and alterations of NMDA receptor function. Eur. J. Neurosci. 21, 2837–2844. (2005).